Neonatal life science
ProPrems contains three defined bacterial strains and is manufactured in Europe under strict quality and safety standards.
NeoMega36 is specifically formulated for preterm infants, providing ARA and DHA at intake levels in line with the 2022 ESPGHAN recommendations.
Our products
Two products, developed exclusively for preterm physiology
High-quality multi-strain probiotic
ProPrems®
ProPrems is a multi-strain high quality food supplement containing three defined bacterial strains: B. longum subsp. infantis Bb-02, B. animalis subsp. lactis BB-12® and S. thermophilus TH-4®.
Each individually packaged single portion provides a total of 1 billion CFU.
ProPrems is manufactured in Europe under controlled processes with defined product specifications and quality controls and is stability-tested throughout its 2-year shelf life.
| Format | 0.5-gram single portion sachet |
| Production and rigorous quality control | Around 6 months from production start to final batch release |
| Production grade | Preterm-infant grade |
| Stability | Stability verified throughout shelf life |
| Storage | Room temperature below 25°C |
| Shelf life | 2 years |
Essential fatty acids for visual development
NeoMega36®
A food for special medical purposes (FSMP) enriched with ARA and DHA, supporting the development of normal vision function in preterm infants.
Helps reduce the “preterm PUFA gap” and aligns with ESPGHAN’s enteral nutrition guidance.
NeoMega36 is supported by academic research in the Nordics. It is developed and manufactured in Europe under strict quality control.
| Format | 5 ml bottle, oral or via NG-tube |
| Daily dosing | 0.4 ml/kg body weight/day (100 mg/kg/day ARA + 50 mg/kg/day DHA) |
| Aligned with | ESPGHAN 2022 recommendations on enteral nutrition for preterm infants |
| Shelf life | An unopened bottle has a shelf life of 12 months. An opened bottle can be used for 7 days. |
| Regulatory footprint | Notified FSMP in most European countries |
Science and medical need
Every preterm birth is a nutritional emergency
More than 15 million infants are born prematurely every year. To avoid lifelong complications from nutritional deficits, they need more energy per kilogram of body weight than a Tour de France cyclist.* But in the NICU, nutrition competes with many other urgent priorities.
Born before the nutrient reserves are built.
Most of a baby’s nutrient reserves (fat, protein, iron, calcium, phosphorus and long-chain fatty acids like DHA) are laid down in the last trimester. The earlier a baby is born, the smaller those stores are, and the greater the gap nutrition has to close.
Higher needs, immature systems.
Preterm infants need more of most nutrients than infants born at term. At the same time, an immature gut and metabolism make it harder to digest, absorb and use what they are given.
A critical window for brain development.
The brain develops rapidly during the weeks a preterm infant spends in the NICU. Getting nutrition right during this window matters for long-term growth and neurodevelopment.
Sources:
Embleton ND, Jennifer Moltu S, Lapillonne A, et al. Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts. J Pediatr Gastroenterol Nutr. 2023;76(2):248–268. doi:10.1097/MPG.0000000000003642
Many nutritional challenges for preterm infants in the NICU.
- High demands and insufficient supplies
- Immature gut and poor absorption
- Risks of rapidly increasing intakes
Quality & safety
ProPrems®
- High strain quality: defined strain identity, low MIC-values, no transferable antibiotic-resistant genes (plasmids)
- Rigorous and expanded contaminant testing before, during and after production
- No D-lactate production
- Stability tested throughout the 2-year shelf life
- Defined quality-control testing before batch release
- Individually packaged single portions, simplifying handling prior to use
NeoMega36®
- Manufacturing subject to stringent quality control protocols ensuring batch-to-batch consistency and traceability
- Supported by stability and microbiological analytics confirming chemical integrity and microbial safety throughout shelf life and in-use period
- Stable for up to 7 days once opened
- Manufactured in Europe
Product information
ProPrems®
NeoMega36®
Frequently asked questions
What is the difference between a food supplement and a Food for Special Medical Purposes (FSMP)?
Food supplements are intended to supplement the normal diet and are concentrated sources of nutrients or other substances with a nutritional or physiological effect, supplied in dose form.
FSMPs are specially formulated for the dietary management of patients with particular nutritional requirements and are intended to be used under medical supervision.
ProPrems® is classified as a food supplement in most countries where it is available, although its regulatory classification may vary by market. NeoMega36® is a Food for Special Medical Purposes (FSMP). Please refer to the product information applicable in your country for local regulatory information.
In which countries are ProPrems® and NeoMega36® available?
Availability varies by product and country. Please contact Neobiomics for personalised information.
Where is Neobiomics based, and where are its products manufactured?
Neobiomics is headquartered in Sweden, and both ProPrems® and NeoMega36® are manufactured in the European Union. Each product is manufactured and tested according to its respective product specifications and quality requirements.
Where can healthcare professionals find more information about Neobiomics products?
Further product information and scientific resources intended for healthcare professionals are available through the dedicated ProPrems® and NeoMega36® websites. We also regularly participate in scientific congresses, conferences and symposia. Visit our News section to see where you can meet our team and learn more about upcoming activities.
What does “defined bacterial strains” mean?
A bacterial strain is a specific variant within a bacterial species, identified by a unique strain designation. ProPrems® contains three defined strains: B. longum subsp. infantis Bb-02, B. animalis subsp. lactis BB-12® and S. thermophilus TH-4®.
Identifying microorganisms at strain level provides precise information about the bacterial strains contained in the product and allows their identity and characteristics to be documented and controlled throughout manufacturing and quality testing.
What quality controls are performed for ProPrems®?
From the start of production to final batch release, a process that takes approximately six months, ProPrems® undergoes quality-control and microbiological testing at different stages. This includes testing for microbial contaminants during the production process, as well as defined quality-control testing before final batch release.
How is ProPrems® supplied?
How does NeoMega36 reduce the “preterm PUFA gap”?
NeoMega36® reduces the “preterm PUFA gap” by providing early, balanced and targeted supplementation of DHA and ARA to replace the fatty acids that preterm infants miss from late-gestation placental transfer.